Low-resource settings refer to environments with limited access to basic necessities such as healthcare, education, infrastructure, and technology. In the context of research, low-resource settings typically involve populations in developing countries or marginalized communities with limited resources and funding for conducting studies. Researchers working in low-resource settings face challenges such as lack of infrastructure for data collection, limited access to technology and academic resources, and difficulties in recruiting and retaining study participants. Despite these challenges, research in low-resource settings is crucial for addressing issues such as poverty, health disparities, and social inequities. Studies conducted in low-resource settings often focus on finding cost-effective solutions to improve health outcomes, education, and economic development. Researchers in this area may prioritize community engagement, capacity-building, and collaboration with local stakeholders to ensure the relevance and sustainability of their research efforts. Overall, research in low-resource settings plays a critical role in advancing knowledge and addressing the needs of vulnerable and underserved populations around the world.